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Everything here is reference information drawn from the research literature, not medical advice, and Lamduan is neither a doctor nor a pharmacist. Supplements are not medicines and do not replace anything a doctor has prescribed. If you take regular medication, are pregnant or breastfeeding, have liver or kidney disease, or have surgery coming up, speak to a pharmacist or doctor before starting anything on this page.
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The B vitamin behind neurotransmitter synthesis and protein handling.
🎯What it helps withModerate
Nausea in pregnancy, and premenstrual symptoms.
⚗️Effect on hormonesWeak
Modestly lowers prolactin at high doses. No effect on testosterone.
Weight and fat lossNo human data
Nothing to do with fat loss.
🌙SleepWeak
People report more vivid dreams; no trial has measured actual sleep quality.
❤️Other health effectsModerate
Nervous system and haemoglobin synthesis.
📏Dose and ceiling
Commonly used: 2-50 mg per day
100 mg/day — IOM. EFSA cut theirs to 12 mg/day in 2023, an eightfold gap. For long-term use, follow the lower number.
When to take it
Take with food.
Caution
A water-soluble vitamin that genuinely causes toxicity. High doses over months to years cause sensory nerve damage — numbness, pins and needles, unsteady walking. Cases are reported below 500 mg/day. Usually reversible on stopping, but not always.