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Everything here is reference information drawn from the research literature, not medical advice, and Lamduan is neither a doctor nor a pharmacist. Supplements are not medicines and do not replace anything a doctor has prescribed. If you take regular medication, are pregnant or breastfeeding, have liver or kidney disease, or have surgery coming up, speak to a pharmacist or doctor before starting anything on this page.
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A B vitamin in two very different forms. Nicotinic acid causes flushing and lowers blood lipids; nicotinamide does neither.
🎯What it helps withModerate
High doses genuinely lower triglycerides and raise HDL, but outcome trials found no reduction in heart disease, so it has fallen out of use as a primary treatment.
⚗️Effect on hormonesModerate
At 1,500 mg and above it causes insulin resistance and raises blood glucose — a clear adverse effect.
Weight and fat lossNo human data
Does not reduce body fat, even though it changes the numbers on a lipid panel.
🌙SleepNo human data
Nothing to do with sleep, though the flush can be disruptive if taken at bedtime.
❤️Other health effectsModerate
Energy metabolism and skin.
📏Dose and ceiling
Commonly used: 16-500 mg per day
35 mg/day — IOM, but that number is set on the skin-flushing threshold, not on toxicity. Liver injury needs 1,000-3,000 mg/day for months. Crossing this ceiling is worth knowing about, not worth panicking over.
When to take it
Take with food.
Caution
At 1,000-3,000 mg/day it can inflame the liver, and extended-release forms are markedly riskier than plain ones. Do not self-prescribe high doses.