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Everything here is reference information drawn from the research literature, not medical advice, and Lamduan is neither a doctor nor a pharmacist. Supplements are not medicines and do not replace anything a doctor has prescribed. If you take regular medication, are pregnant or breastfeeding, have liver or kidney disease, or have surgery coming up, speak to a pharmacist or doctor before starting anything on this page.
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Tap a name for all six answers. Every answer carries a badge saying how strong the evidence is, and where the marketing does not match the research, it says so plainly.
The vitamin that lets certain proteins bind calcium in the right place. MK-7 stays in the blood far longer than MK-4, so once a day is enough.
🎯What it helps withModerate
Blood markers of arterial calcium handling improve clearly, but the two trials that measured actual arterial imaging came out neutral.
⚗️Effect on hormonesNo human data
No measurable effect on hormones in humans.
Weight and fat lossNo human data
Nothing to do with fat loss.
🌙SleepNo human data
Nothing to do with sleep.
❤️Other health effectsModerate
Bone and blood vessels. The marketing line that vitamin D without K2 will calcify your arteries is not supported at the outcome level — NIH itself calls the role unclear.
📏Dose and ceiling
Commonly used: 45-180 mcg per day
No upper limit set by IOM or EFSA — no toxicity has ever been reported in humans or animals.
When to take it
Take with a meal containing fat, or it will not absorb.
Caution
No toxicity at any dose. The real risk is pharmacological, not toxic.
Interacts with medicines
Directly antagonises warfarin, whose whole mechanism is blocking vitamin K. If you take warfarin, never start or stop this on your own — talk to your doctor, keep the intake rigidly constant and monitor INR.